Maziren wan
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| Kind | Traditional medicine |
|---|---|
| Part of the plant | Seed |
| Also called | MaZiRenWan Ma zi ren wan maren wan (麻仁丸) piyue wan (脾約丸) |
| Language | Chinese |
Maziren wan (麻子仁丸, mázǐrén wán, "cannabis seed pill") is a honey pill of Chinese medicine for constipation, made of cannabis seed and five other drugs. The physician Zhang Zhongjing first recorded it around the 2nd century AD, and it is still prescribed. The seed it is named after, huǒmárén (火麻仁), is the one part of the plant that Chinese medicine uses in clinical practice today.[1]
Making maziren wan
In the Song edition of Zhang Zhongjing's Shanghan lun (傷寒論, "Treatise on Cold Damage") the pill is made of two sheng of cannabis seed (麻子仁), half a jin of peony root (芍藥), half a jin of roasted bitter orange (枳實), one jin of peeled rhubarb root (大黃), one chi of roasted and peeled magnolia bark (厚朴) and one sheng of apricot kernels (杏仁), skinned, roasted and pounded separately into a paste. The six are worked with honey into pills the size of a parasol-tree seed. Ten are taken with water three times a day and the dose is raised gradually until it acts.[2]
The pill is for hard stools with frequent urination, the condition that the Shanghan lun calls "the spleen is constrained" (其脾為約).[2] In the annotated edition of Cheng Wuji the pill is maren wan (麻仁丸), and his note calls it piyue wan (脾約丸), "the spleen-constraint pill".[3]
The Zhenglei bencao of 1108 copies the formula as Zhang Zhongjing's, with a full jin of bitter orange, the pills taken after meals with jiāngshuǐ (漿水).[4][1] Li Shizhen repeated it in the Bencao gangmu of 1593 among the prescriptions under the seed of cannabis (大麻).[5][1]
Use
In 2003 maziren wan ranked 40th of the 301 formulas most often prescribed for reimbursement by Taiwan's National Health Insurance, with more than 10,705 kg of concentrated dry extract prescribed that year.[1] A randomised trial of 291 patients with functional constipation, at eight clinics in Hong Kong from 2013 to 2015, compared it with senna and a placebo. Its authors found it well tolerated and effective, but not apparently more effective than senna.[6] A review of 17 trials from East Asia, which its authors rated at moderate to high risk of bias, judged it effective in Asian patients with functional constipation.[7]
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Brand, E. Joseph; Zhao, Zhongzhen (2017). "Cannabis in Chinese medicine: are some traditional indications referenced in ancient literature related to cannabinoids?". Frontiers in Pharmacology. 8 108. doi:10.3389/fphar.2017.00108.
- ↑ 2.0 2.1 張仲景 (Zhang Zhongjing). "卷第五：辨陽明病脈證並治第八". 傷寒論 [Treatise on Cold Damage] (in 中文). Edited by 林億 (Lin Yi) and others (Song ed.). Retrieved 29 October 2026 – via Wikisource.
- ↑ 成無己 (Cheng Wuji). "卷五：辨陽明病脉證并治法第八". 傷寒論注釋 [Treatise on Cold Damage, annotated] (in 中文) (Siku quanshu ed.). Retrieved 29 October 2026 – via Wikisource.
- ↑ 唐慎微 (Tang Shenwei). "卷二十四：麻蕡". 證類本草 [Materia Medica Arranged by Classification] (in 中文) (Siku quanshu ed.). Retrieved 3 October 2026 – via Wikisource.
- ↑ 李時珍 (Li Shizhen). "卷二十二：穀之一（胡麻；大麻）". 本草綱目 [Compendium of Materia Medica] (in 中文) (Siku quanshu ed.). Retrieved 3 October 2026 – via Wikisource.
- ↑ Zhong, Linda L.D.; Cheng, Chung-wah; Kun, Wai; et al. (2019). "Efficacy of MaZiRenWan, a Chinese herbal medicine, in patients with functional constipation in a randomized controlled trial". Clinical Gastroenterology and Hepatology. 17 (7): 1303–1310.e18. doi:10.1016/j.cgh.2018.04.005.
- ↑ Yang, Mingxiao; Feng, Ye; Zhang, Yi Lily; Smith, Colleen M.; Hou, Yen-Nien; Wang, Hui; Deng, Gary; Mao, Jun J. (2021). "Herbal formula MaZiRenWan (Hemp Seed Pill) for constipation: a systematic review with meta-analysis". Phytomedicine. 82 153459. doi:10.1016/j.phymed.2021.153459.