Research:2026-04-28/Journal article/haplotype-resolved-regulation-of-secondary-metabolism-in-cannabis

ResearchJournal article28 April 2026

Haplotype-resolved regulation of secondary metabolism in cannabis

Sen Cai, Zhiyuan Zhang, Xiang Li, Yucheng Zhao, Chengwei Lin, Manru Huang, Mingwei Shen, Deyong Ao, Yaxing Li, Shijun You, Nirit Bernstein, Kailei Tang, Yuanyuan Liu

Horticulture Research

Presents a fully phased, chromosome-level genome of CSLZ, a wild diploid accession grown from cuttings of mother plants collected in Linzhi County, Tibet, at about 3,100 m. Comparing the two haplotypes, the authors find that structural variants and transposable-element insertions shape the alleles of biosynthetic genes, with examples including a haplotype-specific loss of germacrene D synthase activity, copy-number variation in oxidosqualene cyclases and a silenced flavonoid glycosyltransferase allele. Allele-specific expression is traced across six tissues and nine flowering stages. The authors suggest that this allelic divergence is a feature of wild populations that breeding of modern cultivars may have reduced. It adds a wild Tibetan accession to the cannabis genome assemblies in this corpus.

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DOI10.1093/hr/uhag159

CountryChina

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2026-04-28 2026-10-15 Haplotype-resolved regulation of secondary metabolism in cannabis Journal article Genetics Sen Cai, Zhiyuan Zhang, Xiang Li, Yucheng Zhao, Chengwei Lin, Manru Huang, Mingwei Shen, Deyong Ao, Yaxing Li, Shijun You, Nirit Bernstein, Kailei Tang, Yuanyuan Liu Horticulture Research 2026 10.1093/hr/uhag159 https://doi.org/10.1093/hr/uhag159 Presents a fully phased, chromosome-level genome of CSLZ, a wild diploid accession grown from cuttings of mother plants collected in Linzhi County, Tibet, at about 3,100 m. Comparing the two haplotypes, the authors find that structural variants and transposable-element insertions shape the alleles of biosynthetic genes, with examples including a haplotype-specific loss of germacrene D synthase activity, copy-number variation in oxidosqualene cyclases and a silenced flavonoid glycosyltransferase allele. Allele-specific expression is traced across six tissues and nine flowering stages. The authors suggest that this allelic divergence is a feature of wild populations that breeding of modern cultivars may have reduced. It adds a wild Tibetan accession to the cannabis genome assemblies in this corpus. China