Research:2026-03-24/Journal article/expansion-and-functional-diversification-of-terpene-synthases-shape-volatile-terpenoid-landscape-in-cannabis-s

ResearchJournal article24 March 2026

Expansion and functional diversification of terpene synthases shape volatile terpenoid landscape in Cannabis sativa

Yaolei Mi, Mofan Zhang, Kaiquan Zhang, Jun Li, Song Yan, Xuewen Zhu, Liwei Wang, Yupeng Du, Sifan Wang, Xue Cao, Shilin Chen, Zhichao Xu, Wei Sun

Acta Pharmaceutica Sinica B

Analyses the terpene synthase gene family of Cannabis sativa using haplotype-resolved genome data, volatile profiling, transcriptomics and enzyme assays. Profiling of 28 samples from six cultivars across developmental stages identified 227 volatile terpenes, 88 monoterpenes and 139 sesquiterpenes, with patterns specific to tissue, stage and cultivar. Genome annotation found 41 full-length terpene synthase genes, expanded into subfamily clusters that differ between haplotypes, and the authors separate a core set highly expressed in inflorescences from genes regulated by cultivar. Six previously unreported enzymes showed mono- and sesquiterpene synthase activity, including substrate promiscuity across subfamilies.

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DOI10.1016/j.apsb.2026.03.035

Record created 15 October 2026maintained by landrace.wiki editorspage history

2026-03-24 2026-10-15 Expansion and functional diversification of terpene synthases shape volatile terpenoid landscape in Cannabis sativa Journal article Chemistry Yaolei Mi, Mofan Zhang, Kaiquan Zhang, Jun Li, Song Yan, Xuewen Zhu, Liwei Wang, Yupeng Du, Sifan Wang, Xue Cao, Shilin Chen, Zhichao Xu, Wei Sun Acta Pharmaceutica Sinica B 2026 10.1016/j.apsb.2026.03.035 https://doi.org/10.1016/j.apsb.2026.03.035 Analyses the terpene synthase gene family of Cannabis sativa using haplotype-resolved genome data, volatile profiling, transcriptomics and enzyme assays. Profiling of 28 samples from six cultivars across developmental stages identified 227 volatile terpenes, 88 monoterpenes and 139 sesquiterpenes, with patterns specific to tissue, stage and cultivar. Genome annotation found 41 full-length terpene synthase genes, expanded into subfamily clusters that differ between haplotypes, and the authors separate a core set highly expressed in inflorescences from genes regulated by cultivar. Six previously unreported enzymes showed mono- and sesquiterpene synthase activity, including substrate promiscuity across subfamilies.