Talk:Cannabidiol

Talk

Discussion for: Cannabidiol • View • Links • Related changes

Use this page for verification notes, disputes, and action items. Keep narrative content on the article.

Page scope

Cannabidiol covers cannabidiol as a product of the cannabis plant: how the plant makes its acid, the enzyme and genes behind it, the compound's structure and stability, how CBD content differs between chemotypes, hemp, landraces and modern cultivars, its isolation and its action at receptors. The acid itself is treated at Cannabidiolic acid, the enzyme at CBDA synthase, the classification of plants by cannabinoid ratio at Chemotype and the receptors at Cannabinoid receptors. Medical and other uses of cannabis belong to the articles on those uses.

Data verification

Record source conflicts, dating problems and sources not used here. Keep narrative content on the article.

Discussion

Sources and how they were read

The journal papers cited were read in full in the publishers' open texts or in PubMed Central, and every citation was checked against its Crossref record. Taura and colleagues (1996) was read on the journal's open page and Taura and colleagues (2007) and Hillig and Mahlberg (2004) on the publishers' free-access pages. McPartland and Small (2020) was read in the publisher's PDF, from which the page number is taken. The UNODC manual of 2009 (ST/NAR/40) was read in the PDF on the UNODC site; page numbers are the printed ones. Adams, Hunt and Clark (1940) is cited for its title and date; the account of the isolation comes from Pertwee (2006) and Golombek and colleagues (2020).

Where the sources disagree

• Oxygen and cofactor in the CBDA synthase reaction. Taura and colleagues (1996) found that the purified enzyme needed no coenzyme, cofactor or molecular oxygen. The same group (2007), working with the cloned enzyme, found a covalently bound FAD and a reaction that depends on oxygen and releases hydrogen peroxide. The article gives the later finding and says that it revised the earlier one.
• Whether the THCA and CBDA synthases are alleles. Hillig and Mahlberg (2004) worked with the single-locus model of de Meijer and colleagues (2003); Laverty and colleagues (2019) found the two genes at separate, closely linked loci. The article gives both.
• THC to CBD ratio in United States seizures, 1995. ElSohly and colleagues (2016) give the 1995 ratio as 14 in their abstract and as about 15 in the text. The article uses the abstract's figure.

Not used

• De Meijer and colleagues (2003) and Small and Beckstead (1973) were not read; their findings are described from Hillig and Mahlberg (2004) and Laverty and colleagues (2019) and attributed.
• Mechoulam and Shvo (1963), the paper that gave the structure of CBD, was not read; the date and attribution come from Pertwee (2006).
• A 2025 paper on Moroccan cannabis policy, cited on Hashish for an export of CBD-rich hashish in 2023, could not be read and is not used here.
• Clinical trials, medical approvals by country and the legal status of CBD products are outside the page's scope; the article states only that CBD is approved as a prescription medicine and sold over the counter, from Golombek and colleagues (2020).

Images reserved in the article

One image has a place in the article but is not yet uploaded. Its file link is kept hidden in the page source and can be restored once the file exists:

• File:Cannabis-cannabidiol-structure.jpg (series box, lead image), a structural diagram to be drawn of (−)-cannabidiol: a resorcinol ring with two hydroxyl groups and a five-carbon side chain, bonded to a cyclohexene ring bearing a methyl group and an isopropenyl group, with no ring closure between them. Public-domain structure drawings of the molecule exist on Wikimedia Commons and can serve as a model.